Contrave contraindications

Contrave contraindications combine the contraindications list to Bupropion and Naltrexone (Contrave pills active ingredients). A new anti-obesity drug, Contrave, is contraindicated in patients with diagnosed hypersensitivity to Bupropion and Naltrexone.

Contrave is contraindicated in pediatric (up to 18 y.o.) and elderly (over 65 years) age. Given that Contrave affects the CNS, its use is contraindicated in pregnancy and during pregnancy planning. Contrave is contraindicated during lactation as well.

There is no precise data on the penetration of Contrave in breast milk. However, given that almost all pharmaceutical substances pass into human milk, nursing mothers should not use Contrave drug.

Obese and overweight patients with severe liver and kidney failure should not take Contrave. Patients with renal and (or) hepatic insufficiency should use other weight loss drugs.

Bupropion (one of Contrave active ingredients) is contraindicated in obese patients with epilepsy, a history of seizures, Parkinson’s disease and Alzheimer’s disease. Therefore, Contrave weight loss drug (Bupropion; Naltrexone) is contraindicated in people with these pathologies.

Naltrexone (one of Contrave active ingredients) is contraindicated in patients with hemodyscrasia.  Therefore, before taking Contrave (Naltrexone; Bupropion), make sure you have no hemodyscrasia.  Moreover, Contrave is contraindicated in:

  • Oncology diseases
  • Autoimmune diseases

This is not a complete list of Contrave drug contraindications. Contrave clinical research is not yet over. Therefore, the contraindications list of this drug may be extended.

According to published data, Contrave may affect the cardiovascular system. Therefore, it is possible that after clinical trials end, the combined weight loss drug, Contrave, will be contraindicated in obese and overweight patients with cardiovascular diseases.